HIV Replication 3D Medical Animation Video

It is a very excellent animation which explains the hiv replication very clearly.
For free download of this video please visit my webpage
http://3dmed.wetpaint.com/
And other 3D animation videos visit
http://3dmed.wetpaint.com/page/3D+Medical+Animation+Library
Regards,
Dr.Rufus

The Lyrics of this video is here

Targeting HIV replication

The replication of HIV 1 is a multi-stage process.

Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs.

Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte.

Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4.

These receptors interact with protein-complexes, which are embedded in the viral envelope.

These complexes are composed of two glycoproteins:

an extracellular gp 120 and
a transmembrane gp 41

When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment.

It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120.

This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane.

Gp 41 then folds back on itself.

This draws the virus towards the cell and facilitates the fusion of their membranes.

The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes:

Integrase, Protease and Reverse Transcriptase.

Reverse Transcriptase begins the reverse transcription of viral RNA.

It has two catalytic domains:

The Ribonuclease-H active site

And the polymerase active site

Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA.

The polymerase then completes the remaining DNA-strand to form a DNA -- double helix.

Now Integrase goes into action.

It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends.

Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome.

The host cell genome now contains the genetic information of HIV.

Activation of the cell induces transcription of proviral DNA into messenger RNA.

The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised.

Some of them have to be processed by the viral protease.

Protease cleaves longer proteins into smaller core proteins.

This step is crucial to create an infectious virus.

Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid.

This immature particle leaves the cell acquiring a new envelope of host and viral proteins.

The virus matures and becomes ready to infect other cells.

HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression.

Drugs which interfere with the key steps of viral replication can stop this fatal process.

Entry into the host cell can be blocked by fusion inhibitors for example.

Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens.

The action of Integrase can be blocked.

Protease inhibitors are also part of standard antiretroviral therapy.

Each blocked step in viral replication is a step towards better control of HIV disease.


Script, Storyboard, Art Direction by: Frank Schauder, MD
Animation: MACKEVISION
Publicity: Dr.Rufus Rajadurai.MD.,D.DiaDENS.,

I heard that a man ...
I heard that a man has cured himself by? a so called f*gcination. Has anyone tried it ?

@grislytooth1 Lmao ...
@grislytooth1 Lmao :D That is so0o0o0 funny?

HIV, you are an? ...
HIV, you are an? a*****e.

Thank goodness for ...
Thank goodness for this disease. Allah, in His wisdom, sent? it as punishment for deviancy.

Asta e filmuletul ...
Asta e filmuletul pe care? l-a expus Crisan la Infectioase!

had no clue what ...
had no clue what they were talking? about, but it definitely looked scary. lol

I used to be an ...
I used to be an adventurer like you, but then I took HIV to the? cell.

thank you, very ...
thank you, very helpful for? my study

best? video on HIV ...
best? video on HIV i've watched so far. thank you.

ok.and can u say ...
ok.and can u say me? 1 thing , flu virus have RNA or DNA?

HOLY MOTHER OFF ...
HOLY MOTHER OFF JESUS were screwed.... ?

@arnoldasakva it ...
@arnoldasakva it might be possible, but i think the virus replication will fail. rna is the messenger of genetic info. it has to have genetic? info to tell the enzymes for infection.

fake? s**tf**k
fake? s**tf**k

@blackpythonsc ever ...
@blackpythonsc ever heard of electron microscopes? ???

no human? have ever ...
no human? have ever seen a single HIV virus.. how could anyone prove it ever existed?

Great artwork for a ...
Great artwork for a virus that has never been isolated. Amazing HIV propaganda. See "House of Numbers" for the science that? the medical machine doesn't want you to see. Stop the tests, stop the murder. Medical experts especially should see this important info to live up to the ethics of their profession.

OMG! Why so many ...
OMG! Why so many guys and girls on the site == datingpoz...C óM == are very sexy? Why so many people are? infected by HIV? There is no doubt that we need SEX-ED

And i wonder what ...
And i wonder what happen if virus's? RNA-DNA double strand merge with cell's DNA?

s**t! I have a ...
s**t! I have a final exam on tomorrow about this. And he said we have to say this? in our own word.

Trippy. But viruses ...
Trippy. But viruses are still not "alive"? because when isolated they are biologically inert

Then in 1999, an ...
Then in 1999, an international team of researchers reported that they had discovered the origins of HIV-1, the predominant strain of HIV in the developed world. A subspecies of chimpanzees native to west equatorial Africa had been identified as the original source of the virus. The researchers believe that HIV-1? was introduced into the human population when hunters became exposed to infected blood

HIV is transmitted ...
HIV is transmitted ONLY through blood, semen, and vaginal secretions. Therefore sweat, tears, saliva, vomit, feces and urine do not contain the virus. There have? been many studies done to confirm this information.

MA? IN ITALIANO NO? ...
MA? IN ITALIANO NO???

I thought HIV virus ...
I thought HIV virus have only two? enzymes.

@jamilbigj The ...
@jamilbigj The enzyme reverse transcriptase? takes the single strand of RNA and degrades the strand while making a single strand of DNA at the same time. The degraded RNA strand is then converted into another single strand of DNA. This makes a double stand of DNA which is incorporated into our genome. New enzymes are always made during biosynthesis when the virus becomes active after some time. Without reverse transcriptase, HIV wouldn't be able to infect our host cells.

this is so ...
this is so complicated... and? they do this without any brains

@Bach2rehab A) FOOL ...
@Bach2rehab A) FOOL! All bodily fluids contain the virus, And Saliva is what? Push yourself off a cliff now loser! B) There are some sick f**ks in the world that do that s**t, but with your sheltered life you would probably have never realized this without experiencing it through your own computer screen. Cheers? Really? Are you some kind of wannabe Brit-f*g? You lose everything. Have a nice? death.

So, I am assuming ...
So, I am assuming the two viral RNA strands at the end are created from the original RNA strand? Can reverse transcriptase do that? Also, since every new cell gets its own share of the 3 crucial enzymes,? does it get new enzymes from the new proteins that are created?

@DatSlowpoke HAHAHA ...
@DatSlowpoke HAHAHA! You sir are an idiot... Evidently you know nothing about HIV and how it's transmitted. A) Saliva doesn't contain the HIV virus so biting? someone won't infect them. B) f**ked a monkey... really? Do I even have to address that?... Cheers, I'm done entertaining your uneducated spew of nonsense.

I'm in Pharmacology ...
I'm in Pharmacology and Pathophysiology and? this video is very helpful in understanding HIV pathophysiology and the pharmacology of antiretrovirals. Thank you!

---